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The most common cause of smell loss is an obstruction in the nose. In order to smell, she says, the odorants must go up the nose to the superior nasal region called the olfactory neuroepithelium, past narrow mucus lined canals 1 to 2 millimeters wide on both sides of the inner nose. An obstruction in the lower part of the nose, caused by a cold, for example, or a very slight obstruction higher up in the specialized tissue, can close off the smell system from odorants, Mott says.

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